Everything about Aggrecan totally explained
| Name = Aggrecan
| HGNCid = 319
| Symbol = ACAN
| AltSymbols =; AGC1; AGCAN; CSPG1; CSPGCP; MSK16; SEDK
| OMIM = 155760
| ECnumber =
| Homologene =
| MGIid =
| GeneAtlas_image1 = PBB_GE_ACAN_207692_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ACAN_205679_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_ACAN_217161_x_at_tn.png
| Function =
| Component =
| Process =
| Orthologs =
}}
Aggrecan, or
large aggregating proteoglycan, is a
proteoglycan, or a
protein modified with
carbohydrates; the
human form of the protein is 2316
amino acids long and can be expressed in multiple isoforms due to
alternative splicing. Along with
Type-II collagen, aggrecan forms a major structural component of
cartilage, particularly
articular cartilage. Aggrecan consists of two
globular structural domains at the
N-terminal end and one globular domain at the
C-terminal end, separated by a large domain heavily modified with
glycosaminoglycans. The two main modifier moieties are themselves arranged into distinct regions, a
chondroitin sulfate and a
keratan sulfate region.
The linker domain between the N-terminal globular domains, called the interglobular domain, is highly sensitive to
proteolysis. Such degradation has been associated with the development of
arthritis.
Proteases capable of degrading aggrecans are called
aggrecanases, and they're members of the
ADAM (A
Disintegrin And
Metalloprotease) protein family.
Further Information
Get more info on 'Aggrecan'.
|
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